Ampk in the Regulation of Autophagy, Cancers and Cellular Transport

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The nutrient and energy sensor AMP-activated protein Kinase regulates cellular and whole-body energy homeostasis through stimulating catabolic ATP-generating and suppressing anabolic ATP-consuming pathways thereby helping cells survive during energy starvation. AMPK plays an important role in autophagy induction in response to starvation, a process that involves phosphorylating TSC2 and mTOR activation. Recent advances indicate the kinase also to exert tumor suppressor activity by stimulating apoptosis, autophagy and cell ...

Ampk in the Regulation of Autophagy, Cancers and Cellular Transport 2014, LAP Lambert Academic Publishing

ISBN-13: 9783659593345

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