Researchers offer an authoritative analysis of the findings on the rapid development of antisense oligonucleotides therapeutics and their application in various in vivo model systems. They provide an account of state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vivo biological ...
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Researchers offer an authoritative analysis of the findings on the rapid development of antisense oligonucleotides therapeutics and their application in various in vivo model systems. They provide an account of state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vivo biological activity, the pharmacology and pharmocokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.
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