In clinical trials, monitoring accumulating data at regular intervals is essential for balancing ethical and financial considerations against scientific rigor. This comprehensive second edition reflects the remarkable evolution in adaptive clinical trial methodology over the past two decades. Since publication of the first edition, these approaches have transformed from theoretical concepts to widely accepted practices, now endorsed by regulatory authorities, including formal FDA guidance. Features Eleven entirely new ...
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In clinical trials, monitoring accumulating data at regular intervals is essential for balancing ethical and financial considerations against scientific rigor. This comprehensive second edition reflects the remarkable evolution in adaptive clinical trial methodology over the past two decades. Since publication of the first edition, these approaches have transformed from theoretical concepts to widely accepted practices, now endorsed by regulatory authorities, including formal FDA guidance. Features Eleven entirely new chapters, including optimal design construction, delayed "pipeline" data accommodation, and multiple comparison procedures Eight dedicated chapters on adaptive methods including sample size re-assessment, seamless Phase II/III trials, multi-arm multi-stage trials, and enrichment designs Exact methods for binary and Poisson data with applications to vaccine trials Expanded discussion of binding versus non-binding futility boundaries for enhanced decision-making A chapter with a thoroughly updated review of Bayesian approaches to sequential trial design and analysis Incorporates response-adaptive treatment assignment in group sequential designs Practical computational methods and software guidance for implementing the techniques This definitive resource serves statisticians, clinical researchers, pharmaceutical scientists, and regulatory professionals involved in clinical trial design and analysis. The text balances theoretical foundations with practical implementation guidance, making it invaluable for both experienced practitioners and those new to adaptive trial methodology. With twice the content of the first edition, Group Sequential and Adaptive Methods for Clinical Trials, Second Edition provides the comprehensive understanding needed to design more efficient, ethical, and scientifically rigorous clinical trials, ultimately accelerating the delivery of effective treatments to patients.
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Add this copy of Group Sequential and Adaptive Methods for Clinical to cart. $103.44, new condition, Sold by GreatBookPricesUK5 rated 5.0 out of 5 stars, ships from Castle Donington, DERBYSHIRE, UNITED KINGDOM, published 2011 by CRC Press.
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New. Sewn binding. Cloth over boards. 624 p. Contains: Unspecified, Illustrations, black & white, Line drawings, black & white, Tables, black & white. Chapman & Hall/CRC Biostatistics. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
Add this copy of Group Sequential and Adaptive Methods for Clinical to cart. $126.17, new condition, Sold by Booksplease rated 4.0 out of 5 stars, ships from Southport, MERSEYSIDE, UNITED KINGDOM, published 2011 by CRC Press.
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New. Sewn binding. Cloth over boards. 624 p. Contains: Unspecified, Illustrations, black & white, Line drawings, black & white, Tables, black & white. Chapman & Hall/CRC Biostatistics.
Add this copy of Group Sequential and Adaptive Methods for Clinical to cart. $101.13, new condition, Sold by Basi6 International rated 5.0 out of 5 stars, ships from Irving, TX, UNITED STATES, published 2011 by CRC Press.
Add this copy of Group Sequential and Adaptive Methods for Clinical to cart. $104.48, new condition, Sold by Basi6 International rated 5.0 out of 5 stars, ships from Irving, TX, UNITED STATES, published 2011 by CRC Press.
Add this copy of Group Sequential and Adaptive Methods for Clinical to cart. $105.48, new condition, Sold by Basi6 International rated 5.0 out of 5 stars, ships from Irving, TX, UNITED STATES, published 2011 by CRC Press.
Add this copy of Group Sequential and Adaptive Methods for Clinical to cart. $110.12, new condition, Sold by Basi6 International rated 5.0 out of 5 stars, ships from Irving, TX, UNITED STATES, published 2011 by CRC Press.
