It is now widely accepted that the extracellular matrix (ECM) is a key determinant of tissue-specific gene expression. Signals provided by ECM are transduced by integrins, a large and growing superfamily of transmembrane heterodimeric cell surface receptors that link the ECM to structural and fu- tional elements within the cell. A wide range of cellular phenotypes have been shown to be regulated by integrins, including growth, differentiation, mig- tion, invasion, angiogenesis, and apoptosis. Furthermore, abnormalities of ...
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It is now widely accepted that the extracellular matrix (ECM) is a key determinant of tissue-specific gene expression. Signals provided by ECM are transduced by integrins, a large and growing superfamily of transmembrane heterodimeric cell surface receptors that link the ECM to structural and fu- tional elements within the cell. A wide range of cellular phenotypes have been shown to be regulated by integrins, including growth, differentiation, mig- tion, invasion, angiogenesis, and apoptosis. Furthermore, abnormalities of integrin expression and function have been implicated in the etiology of va- ous pathologic conditions, including cardiovascular disease, inflammatory disorders, and cancer. Thus integrins have emerged as an important class of molecules with wide ranging implications for understanding basic biological processes. In Integrin Protocols we provide a wide-ranging collection of laboratory protocols intended to assist investigators interested in integrins in working productively with these molecules, in studying their expression, and in pot- tially manipulating that expression to define their role(s) in relevant biolo- cal models. Protocols are provided for the analysis of integrin expression both at the RNA and protein levels (Chaps. 2, 5, and 7). Delcommenne and Streuli describe procedures for making rat monoclonal antibodies specific for mouse integrins; Schneller et al. and Arap and Huang describe methods for western blotting of integrins and RT-PCR analysis. Protocols are included that cover the analysis of the functional properties of integrins (Chaps. 1, 3, 4, 8, and 9 through 11). Koivunen et al.
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Add this copy of Integrin Protocols to cart. $26.95, good condition, Sold by The Warm Springs Book Company rated 4.0 out of 5 stars, ships from Fremont, CA, UNITED STATES, published 1999 by Humana Press.
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Good. Ex-library. Sewn binding. Cloth over boards. 296 p. Contains: Illustrations, black & white. Methods in Molecular Biology (Hardcover), 129. Audience: General/trade. An ex-company library copy with some library markers. Book appears unread and otherwise would be a fine copy in pictorial boards; Issued without a DJ. 1st edition. 8vo., 296 pages.
Add this copy of Integrin Protocols [Methods in Molecular Biology, Vol. to cart. $38.00, new condition, Sold by Tiber Books rated 5.0 out of 5 stars, ships from Cockeysville, MD, UNITED STATES, published 1999 by Humana Press, Totowa, N. J.
Add this copy of Integrin Protocols (Methods in Molecular Biology, 129) to cart. $46.75, good condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Santa Clarita, CA, UNITED STATES, published 1999 by Humana.
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Add this copy of Integrin Protocols (Methods in Molecular Biology, 129) to cart. $71.72, new condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Santa Clarita, CA, UNITED STATES, published 1999 by Humana.
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Add this copy of Integrin Protocols (Methods in Molecular Biology) to cart. $77.77, new condition, Sold by Basi6 International rated 5.0 out of 5 stars, ships from Irving, TX, UNITED STATES, published 1999 by Humana.
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New. Print on demand Contains: Illustrations, black & white. Methods in Molecular Biology . XI, 296 p. 24 illus. Intended for professional and scholarly audience.
